Non-perturbative renormalization of tensor currents: strategy and results for Nf= 0 and Nf= 2 QCD: ALPHA Collaboration

Tensor currents are the only quark bilinear operators lacking a non-perturbative determination of their renormalisation group (RG) running between hadronic and electroweak scales. We develop the setup to carry out the computation in lattice QCD via standard recursive finite-size scaling techniques, and provide results for the RG running of tensor currents in Nf= 0 and Nf= 2 QCD in the continuum for various Schrödinger Functional schemes. The matching factors between bare and renormalisation group invariant currents are also determined for a range of values of the lattice spacing relevant for large-volume simulations, thus enabling a fully non-perturbative renormalization of physical amplitudes mediated by tensor current

MACROSCOPIC LESIONS ON THE GREY TRIGGERFISH, BALISTES CAPRISCUS (PISCES) ASSOCIATED WITH THE PRESENCE OF THE PEDUNCULATE BARNACLE, CONCHODERMA VIRGATUM (CIRRIPEDIA, THORACICA)

Fifteen live specimens of Conchoderma virgatum were attached to a grey triggerfish (Balistes capriscus) caught in S.W. Portugal. The barnacles were distributed in three groups (right abdominal external face, anterior side of the insertion of the pelvic spine, and close to (5 mm) the left eye (on the lacrymal bone)). The specimens were very different in size, ranging from 2 mm to 18.9 mm (maximum capitular length, CL). The four largest barnacles (CL 16.4 mm) had egg lamellae. Signs of potential predation on the barnacles (rests of barnacles and half-cut cirri in a barnacle) were detected. The left-eye blindness of the grey trigger fish could have been caused by traumatic action performed by the barnacles that settled close to the eye. The skin surrounding the barnacle cluster attached to the right abdominal external face was inflamed. Skin lesions were of sub-acute or chronic nature and the gall-bladder dilatation was consistent with a prolonged status of injury. Both traumatic and inflammatory lesions could have contributed to the loss of body condition of the grey triggerfish. This study is the first report of C. virgatum in S.W. Portugal and the first record of attachment to a grey triggerfish

Engineered bacteria as therapeutic agents

Although bacteria are generally regarded as the causative agents of infectious diseases, most bacteria inhabiting the human body are non-pathogenic and some of them can be turned, after proper engineering, into ‘smart’ living therapeutics of defined properties for the treatment of different illnesses. This review focuses on recent developments to engineer bacteria for the treatment of diverse human pathologies, including inflammatory bowel diseases, autoimmune disorders, cancer, metabolic diseases and obesity, as well as to combat bacterial and viral infections. We discuss significant advances provided by synthetic biology to fully reprogram bacteria as human therapeutics, including novel measures for strict biocontainment.Ministerio de Economía y Competitividad (MINECO) (BIO2014- 60305R and BIO2011-26689), BACFITERed (SAF2014-56716-REDT)Comunidad Autónoma de Madrid (S2010-BMD-2312)La Caixa FoundationMINECO (BES-2009-02405)Peer reviewe

Comparison of eukaryotic phylogenetic profiling approaches using species tree aware methods

<p>Abstract</p> <p>Background</p> <p>Phylogenetic profiling encompasses an important set of methodologies for <it>in silico </it>high throughput inference of functional relationships between genes. The simplest profiles represent the distribution of gene presence-absence in a set of species as a sequence of 0's and 1's, and it is assumed that functionally related genes will have more similar profiles. The methodology has been successfully used in numerous studies of prokaryotic genomes, although its application in eukaryotes appears problematic, with reported low accuracy due to the complex genomic organization within this domain of life. Recently some groups have proposed an alternative approach based on the correlation of homologous gene group sizes, taking into account all potentially informative genetic events leading to a change in group size, regardless of whether they result in a <it>de novo </it>group gain or total gene group loss.</p> <p>Results</p> <p>We have compared the performance of classical presence-absence and group size based approaches using a large, diverse set of eukaryotic species. In contrast to most previous comparisons in Eukarya, we take into account the species phylogeny. We also compare the approaches using two different group categories, based on orthology and on domain-sharing. Our results confirm a limited overall performance of phylogenetic profiling in eukaryotes. Although group size based approaches initially showed an increase in performance for the domain-sharing based groups, this seems to be an overestimation due to a simplistic negative control dataset and the choice of null hypothesis rejection criteria.</p> <p>Conclusion</p> <p>Presence-absence profiling represents a more accurate classifier of related versus non-related profile pairs, when the profiles under consideration have enough information content. Group size based approaches provide a complementary means of detecting domain or family level co-evolution between groups that may be elusive to presence-absence profiling. Moreover positive correlation between co-evolution scores and functional links imply that these methods could be used to estimate functional distances between gene groups and to cluster them based on their functional relatedness. This study should have important implications for the future development and application of phylogenetic profiling methods, not only in eukaryotic, but also in prokaryotic datasets.</p

Evolutionary Multi-objective Scheduling for Anti-Spam Filtering Throughput Optimization

This paper presents an evolutionary multi-objective optimization problem formulation for the anti-spam filtering problem, addressing both the classification quality criteria (False Positive and False Negative error rates) and email messages classification time (minimization). This approach is compared to single objective problem formulations found in the literature, and its advantages for decision support and flexible/adaptive anti-spam filtering configuration is demonstrated. A study is performed using the Wirebrush4SPAM framework anti-spam filtering and the SpamAssassin email dataset. The NSGA-II evolutionary multi-objective optimization algorithm was applied for the purpose of validating and demonstrating the adoption of this novel approach to the anti-spam filtering optimization problem, formulated from the multi-objective optimization perspective. The results obtained from the experiments demonstrated that this optimization strategy allows the decision maker (anti-spam filtering system administrator) to select among a set of optimal and flexible filter configuration alternatives with respect to classification quality and classification efficiency

Método de análisis biomecánico de la marcha en pacientes portadores de prótesis de rodilla

El análisis de la marcha ha adquirido en los últimos tiempos un extraordinario desarrollo. En la actualidad la ciencia biomecánica ofrece un gran campo de actuación para el estudio de la patología de la deambulación, aplicando los conocimientos anatómicos, las leyes físicas y la alta tecnología (ordenadores, video, plataformas de fuerza, etc ...) En este estudio, se comparan por medio del análisis del movimiento en tres dimensiones, la dinámica y el comportamiento articular de la marcha normal y de la marcha en el paciente portador de protesis de rodilla unilateral y bilateral, para analizar si se aprecian diferencias en las características generales de la marcha y los cambios evolutivos que provocan estas diferencias y sus posibles repercusiones patológicas. La marcha normal tiene una fase de balanceo, seguida de una fase de apoyo con: choque de talón, apoyo del retropié, apoyo de la planta, rodadura sobre el borde extremo, despegue del talón, despegue del primer dedo. Esta dinámica se acompaña de balanceo de las extremidades superiores para mantener el equilibrio y compensar los momentos de inercia provocados por la zancada

An ontology knowledge inspection methodology for quality assessment and continuous improvement

Ontology-learning methods were introduced in the knowledge engineering area to automatically build ontologies from natural language texts related to a domain. Despite the initial appeal of these methods, automatically generated ontologies may have errors, inconsistencies, and a poor design quality, all of which must be manually fixed, in order to maintain the validity and usefulness of automated output. In this work, we propose a methodology to assess ontologies quality (quantitatively and graphically) and to fix ontology inconsistencies minimising design defects. The proposed methodology is based on the Deming cycle and is grounded on quality standards that proved effective in the software engineering domain and present high potential to be extended to knowledge engineering quality management. This paper demonstrates that software engineering quality assessment approaches and techniques can be successfully extended and applied to the ontology-fixing and quality improvement problem. The proposed methodology was validated in a testing ontology, by ontology design quality comparison between a manually created and automatically generated ontology.info:eu-repo/semantics/publishedVersio

Students' physical activity profiles according to children's age and parental educational level

The aim of this study was to identify different profiles of physical activity (PA) behaviors according to the school student’s age stage and their parents’ or guardians education level. Seven hundred twenty-seven students and parents of different educational stages were invited to take part in this study. The participants included, Preschool (1 to 5 years old), Primary School (6 to 11 years old), Secondary School (12 to 15 years old), and High School (16 to 18 years old). A questionnaire to assess the educational level of parents (low, intermediate, and high) and their child’s PA level and sedentary behaviors across various age stages was administered. The results showed a number of different physical activity profiles for preschool (4), primary (6), secondary (7) and high school (2) students. Primary and secondary school children’s behavioral profiles were reported to differ significantly between both physical activity levels and sedentary behaviors, while preschool students’ behavioral profiles only differed between sedentary behaviors. Higher parental education was most prevalent in clusters with significantly higher levels of PA in primary and secondary students, while there were equivocal trends for parental education level influencing behavioral profiles of high school students. These findings suggest there is some association between the behavioral profiles of student’s physical activity and sedentary behavior, and parental education level, most noticeably during the early to middle age stages

Influence of the parental educational level on physical activity in schoolchildren

The factors influencing physical activity participation in children are varied, although there is evidence that the educational level of parents may be one important factor. The aim of this study is to analyze the influence of parental education on the level of physical activity and the sedentary behavior of their children. The parents of 727 students, separated based on school group (preschool: n = 179; primary: n = 284; secondary: n = 230; high: n = 34), were invited to complete a series of questionnaires assessing their educational level (low, intermediate, and high) and their child's level of physical activity and sedentary behavior. Primary school students with high- and intermediate-educated parents were found to engage in significantly more physical activity per week and spent more time engaged in homework than children with lower-educated parents. Secondary school students with higher-educated parents were found to spend significantly less time engaged in sedentary behavior than children with lower- or intermediate-educated parents, and high schoolers with higher-educated parents engaged in less tablet time than children with lower-educated parents. Multiple linear regression demonstrated that greater physical activity was precipitated by certain sedentary behaviors in children with more educated parents, such as total time watching TV (primary school), doing homework (secondary school), and total time using a tablet/similar (high school), which increased total time engaged in physical activity. These findings suggest that more educated parents may implement structured time for their children to engage in a balance of physical activity and sedentary behaviors

Non-perturbative quark mass renormalisation and running in Nf = 3 QCD

We determine from first principles the quark mass anomalous dimension in Nf= 3 QCD between the electroweak and hadronic scales. This allows for a fully non-perturbative connection of the perturbative and non-perturbative regimes of the Standard Model in the hadronic sector. The computation is carried out to high accuracy, employing massless O(a)-improved Wilson quarks and finite-size scaling techniques. We also provide the matching factors required in the renormalisation of light quark masses from lattice computations with O(a)-improved Wilson fermions and a tree-level Symanzik improved gauge action. The total uncertainty due to renormalisation and running in the determination of light quark masses in the SM is thus reduced to about 1